Yes, it can drop like that especially once the iron in the bloodstream is under control. This happens as the iron in the tissue is slowly diminished by the desferal. What this really shows is that the iron in Christian's organs and tissue was never given the opportunity to build up to dangerous levels and that the desferal is working quite well to remove it. I think you will see the ferritin levels stabilize and possibly drop a bit lower. If they drop much below 1000, the doctor may suggest lowering his desferal intake slightly, as desferal can cause problems if there isn't enough iron to chelate. At some point he will also undergo other testing (MRI or Ferriscan) to check iron levels in his liver. This will give a far more accurate reading of his iron stores and how well the chelation is working.