The safety of large doses of resveratrol has not been established, but in limited studies, no side effects have been seen. Even the most fervent proponents of resveratrol agree that more testing is essential, as it has shown some remarkable properties.
If the nose bleed is related to the blood thinning properties of resveratrol, it will be reflected in routine platelet tests. Nose bleeds in children are common and often pollen or dust allergy related, so it may be a coincidence.
Because of the clotting tendencies that exist in thalassemia, the use of supplements with some blood thinning property, such as vitamin E and resveratrol are normally beneficial. However, there are times when platelets can drop, as Sajid experienced not too long ago, and these supplements should be reduced or eliminated until the platelet level is restored. Aspirin can also be included in this group of blood thinners.
As far as resveratrol, the dose for children should be kept in moderation until more research has been done.