Really, whatever goes. After lengthy discussion with doctors and nurses, we reckon it is better to let the pills go in than not. As for my son, he chews them with small chocolate biscuits. Works well. He gags if it is in liquid because it doesn't get disolve completely. Better to be on empty stomach, but as long as it is not after a full meal, it is ok. Full meal just increase the risk of vomitting out when taking the pills.