« on: October 07, 2008, 09:38:01 PM »
For personal use only. by on October 7, 2008.
www.bloodjournal.org From
Randomized controlled trial of deferiprone or deferoxamine in beta-thalassemia
major patients with asymptomatic myocardial siderosis
Dudley J. Pennell, Vasili Berdoukas, Markissia Karagiorga, Vasili Ladis, Antonio Piga, Athanassios Aessopos, Efstathios D. Gotsis,
Mark A. Tanner, Gill C. Smith, Mark A. Westwood, Beatrix Wonke, and Renzo Galanello
Most deaths in beta-thalassemia major result from cardiac complications due to iron overload. Differential effects on myocardial siderosis may exist between different chelators. A randomized controlled trial was performed in 61 patients previously maintained on subcutaneous deferoxamine. The primary end point was the change in myocardial siderosis (myocardial T2*) over 1 year in patients maintained on subcutaneous deferoxamine or those switched to oral deferiprone monotherapy. The dose of deferiprone was 92 mg/kg/d and deferoxamine was 43 mg/kg for 5.7 d/wk. Compliance was 94% 5.3% and 93% 9.7% (P .81), respectively. The improvement in myocardial T2* was significantly greater for deferiprone than deferoxamine (27% vs 13%; P .023). Left ventricular ejection fraction increased significantly more in the deferipronetreated group (3.1% vs 0.3% absolute units; P .003). The changes in liver iron level (0.93 mg/g dry weight vs 1.54 mg/g dry weight; P .40) and serum ferritin level (181 g/L vs 466 g/L; P .16), respectively, were not significantly different between groups. The most frequent adverse events were transient gastrointestinal symptoms for deferipronetreated patients and local reactions at the infusion site for deferoxamine. There were no episodes of agranulocytosis. Deferiprone monotherapy was significantly more effective than deferoxamine over 1 year in improving asymptomatic myocardial siderosis in beta-thalassemia major.
(Blood. 2006;107: 3738-3744)© 2006 by The American Society of Hematology
Note, For complete article , please check the PDF file , attached with this message ...hi Sharmin & Andy if this info is not usefull then you may delete this thread ..
it will b ok .. i will not mind it ...
take care
umair
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Sometimes , God breaks our spirit to save our soul.
Sometimes , He breaks our heart to make us whole.
Sometimes , He sends us pain so we can be stronger.
Sometimes , He sends us failure so we can be humble.
Sometimes , He sends us illness so we can take better care of our selves.
Sometimes , He takes everything away from us so we can learn the value of everything we have.
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Umair