I don't think splenectomy is advisable in many cases. At one time it was a standard practice in thalassemia intermedia, but that thinking is being revised, since long term studies have showed that splenectomy patients have a higher risk of clotting issues and stroke, as the years pass. Now, it is becoming less used and mostly only in cases of vast enlargement or high hemolysis. Even then, doctors are becoming more reluctant to remove the spleen. Its value in thal major is even more limited. I think if at all possible, the spleen should not be removed but sometimes there is no choice.