Decitabine - Clinical Trials in Thalassemia Intermedia

Thanks so much Andy

manal

hi

What is the difference in the workings of  between hydro oxy and decitabine? if both are promoting foetal hb then what will be the advantage if any?

Thanks

Puja

Hi Puja,

Although the purpose of both drugs is to increase fetal hg - from my understanding some patients have good response with hydroxyurea while others did not.  The hope is that decitibine may be more helpful than hydroxyurea in increasing fetal hg and perhaps be effective for more patients. 

Sharmin

Clinical Trials using Decitabine a possible fetal hg inducer in thalassemia intermedia, it would be interesting to see the outcome. 

http://clinicaltrial.gov/ct2/show/locn/NCT00661726

see also http://prsinfo.clinicaltrials.gov/ct2/show/NCT00661726?cond=%22Beta-Thalassemia+Major%22&rank=24

I'm located in Philly...My husband was asked to do this...He is Thal intermedia....We have not given them an answer yet....What do you all think? wow I can't believe I found this today...

I read it...it says this is for phase II...how did phase I go??? Can anyone give me any advice?

Hi Shigvang

Wht is the normal hb your husband maintains?. Actually I have tried hydro oxy , have no expereince on decibatine. I think in this forum there is hardly anyone who has tried this?