abstracts about deficiences in Thalassemia

[bgcolor=#ff2700]β-Thalassemia and its effect on amino acid metabolism [/bgcolor]

http://cat.inist.fr/?aModele=afficheN&cpsidt=16428489

Thyrosin deficiency for example can possible lead to hypothyrodism,because Thyrosin is involved in Thyroxin main production.

[bgcolor=#ff2700]Serum carnitine levels in patients with homozygous beta thalassemia[/bgcolor]
http://www.springerlink.com/content/0q81qmxjdfu7jwly/

[bgcolor=#ff2700]Zinc and copper status of thalassemic children[/bgcolor]

http://www.ncbi.nlm.nih.gov/pubmed/9656419

This makes sense to me,because Copper is involved in red blood cell production,but this also means,that a deficiency in this mineral would be much worse,than it would be for normal people. Perhaps there is a connection between increased Iron absorbation in the gut and increased copper absorbation.

[bgcolor=#ff2700]Magnesium Status of thalassemic patients and rats [/bgcolor] http://www.haematologica.org/cgi/content/abstract/83/2/118
http://cat.inist.fr/?aModele=afficheN&cpsidt=2767209

[bgcolor=#ff2700]Folic acid and thalassemia [/bgcolor] http://www.ams.ac.ir/AIM/0693/0019.pdf

To be continued...

ParkerLewis,

Thank you very much for this information - I look forward to reading the rest

Sharmin

 
effects of vitamin C and selenium on NK activity of patients with β-thalassemia
http://cat.inist.fr/?aModele=afficheN&cpsidt=17857285[/color]
The Benefits of Vitamin C and Vitamin E in Children with b-Thalassemia with High Oxidative Stress
http://www.mat.or.th/journal/index.php?command=preview&selvol=88&selno=4&selids=910

Important for Mayor Patients
Hemochromatosis and Vitamin Chttp://www.annals.org/cgi/content/full/131/6/476

Vitamin D, heart dysfunction tied in thalassemia
http://www.articlearchives.com/medicine-health/diseases-disorders-blood-anemia/259401-1.html

Low serum levels of 25-hydroxy vitamin D in adults affected by thalassemia major or intermedia
http://cat.inist.fr/?aModele=afficheN&cpsidt=17899816

Attenuation of oxidative stress-induced changes in thalassemic erythrocytes by vitamin Ehttp://cat.inist.fr/?aModele=afficheN&cpsidt=15649065

Important here: "The activities of enzymatic antioxidants viz. catalase, glutathione peroxidase and glutathione reductase were found to be drastically reduced in untreated Eβ- and β-thalassemic patients when compared to normal subjects"

The role of vitamin E in the therapy of thalassemia (mayor)
http://www.ncbi.nlm.nih.gov/pubmed/3725609

The effects of beta-carotene and vitamin E on erythrocytes lipid peroxidation in beta-thalassemia patients (mayor)http://journals.mui.ac.ir/jrms/article/viewArticle/1228

Effect of coenzyme Q10 as an antioxidant in β-thalassemia/Hb E patients
http://cat.inist.fr/?aModele=afficheN&cpsidt=18015389

Masked deficit of vitamin B12 in the patient with heterozygous β-thalassemia http://cat.inist.fr/?aModele=afficheN&cpsidt=16437129

Potassium permeability in β-thalassemia minor red blood cells
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=292232

Serum selenium levels in Greek β-thalassemia patients
http://cat.inist.fr/?aModele=afficheN&cpsidt=3408369

this stands in contrast to thal mayor patients with iron overload.
http://www.ncbi.nlm.nih.gov/pubmed/11393640

Increased sensitivity to the inhibitory effect of excess iodide on thyroid function in patients with β-thalassemia major and iron overload and the subsequent development of hypothyroidism
http://cat.inist.fr/?aModele=afficheN&cpsidt=1483474

You are welcome to add some new studies for sure...

Parker Lewis

Thank you somuch for these valuable articles, i will spend some time to finish them all especially that my son was found defiecent in some of them.

Manal

Hi Parker Lewis ,
Good Going  Nice & informative sharing buddy !! .... 

Best Regards
Take Care
Umair

Another nice abstract about fatty acid status in thal minor.
It seems that we are deficient in all unsattered fatty acids.
This is important to me,because fatty acid deficiency can make poor night vision,sensitivity to bright light,eczema,asthma,poor concentration,dry skin,a bad mood,tired,allergic tendencies,hair loss,dry hair,sleep problems (esp.: difficulties in setting at night and waking in the morning),depression,brittle nails
In conjunction with our carnitine deficiency (transporter of Fatty Acids into the cells),this could be a problem
http://medind.nic.in/iaf/t06/i2/iaft06i2p28.pdf

Hi ParkerLewis

It seems that i suffer from almost all these symptoms . I appreciate so much your efforts in posting these articles

manal

No problem...
In my fatty acid screening test last month linolic acid (c18:2),Arachidonacid (20:4),Alpha Lipoic Acid,Homo Gamma Linolic Acid,Gamma Linolic Acid and the Omega 3 Acids were really significantly low.
I am on supplements and extra oil now.My hair is a lot more shinier,but for energy it is to early to tell.

Good luck ParkerLewis and please keep us updated

manal