reaction while using desferal

Keep using deferoxamine and talk to your doctor if you have any of these less serious side effects:

    *

      numbness or burning pain anywhere in the body;
    *

      warmth, redness, or tingly feeling under the skin;
    *

      mild itching or skin rash;

well, finally after diluting desferal in more water my problems are getting better :D :D :D :D!!!!! thank you buddies!!

Local skin reactions

The most common localised reactions include itching,
redness, swelling, lumps, soreness, pain and general discomfort.
The following tips may help reduce such reactions:

(i) Avoid inserting the needle near important blood
vessels or nerves, to minimise the risk of damage
and/or bleeding.

(ii) Check that the DFO has been dissolved in the correct
volume of water (5ml of water for 500mg of DFO). If

(iv) Pain may be reduced by applying topical anaesthetic
necessary, add extra water to further dilute
the solution.

(iii) Change the site chosen for injection. The abdomen is
often the best site. Some patients prefer to use their
upper arm or thigh. However, because localised reac
tions are likely to occur at any site over time, it is
important to use different parts of the body. Over time,
the long-term use of DFO may cause lumps to form
around the injection site. This can be prevented by
rotating sites or, in some but not all cases, by filling
the plastic infusion tubing with a small amount of a
chemical substance known as hyluronidase, before
setting up the pump.
creams such as Emla 30-60 minutes before starting
DFO treatment. Swelling may be reduced by applying
a warm compress on the affected area after DFO
has been administered. For redness, soreness, itching
or swelling, some doctors prescribe heparin cream
or fusicor.

(v) The rate of infusion should also be checked,
as swelling can occur when DFO is administered
too quickly.

(vi) Doctors may also decide to give the patient an antihistamine
before the DFO infusion or, in severe cases,
5-10mg of hydrocortisone may be added to the DFO
solution.

(vii) There are a number of different infuser pumps available
on the market, and patients may find that a different
model better suits their needs. Balloon pumps
are amongst the newest products. These are smaller,
lighter and quieter than the older types. They also
save time and can be more convenient for patients
because the DFO solution used is pre-prepared by
pharmacists, under sterile conditions. Because of these
advantages, such pumps may also improve patients'
compliance to iron chelation therapy. However, the
high cost of these pumps limits their wider use.

(viii) Patients may also wish to try different types of needles,
discussing the pluses and minuses of different types
with their doctor or nurse and other patients. Many
patients prefer small, light needles called "butterfly"
needles of 25 gauge or smaller, inserted at an angle
of about 45 degrees to the skin surface. Other
patients prefer small 'thumbtack' needles that are
inserted vertically through the skin and fixed with
a special tape.


If all of the above mentioned methods fail to relieve the
patient of DFO-related reactions, the use of intravenous
DFO therapy or an alternative chelator should be considered