Doctors learn very little about nutrition in medical school. I have the benefit of a long history of interest in my personal nutrition, so I had a good understanding already in place when I began to learn about thalassemia, and have greatly expanded that knowledge, and much that I learned, I learned from listening to Dr Eliot Vichinsky, who does stress an overall approach to thalassemia treatment, that includes proper nutrients.
Because you have thal major, you have to limit your vitamin C daily intake, as C frees up iron, which helps with chelation, but when you free too much at once, it can reduce heart function. This is also affected by the iron load. If your iron load is high, no more than 250 mg of C should be taken daily. If the iron load is under control, <500 ferritin, higher amounts of C can safely be taken. I do recommend that all thals do get some C, so get some daily. Vitamin E is very important for thals, as it is a powerful antioxidant, but it also has a blood thinning property that is very useful for thals, whose blood contains a lot of "junk", including alpha globin tetramers from the alpha globin unmatched by beta globin, and the results of the ineffective erythropoiesis that takes place in the bone marrow. Vitamins C and E have a synergy, with C being able to restore the antioxidant properties of E, even after it has already been used. IP6 is a good antioxidant and a supplemental iron chelator. It is useful in cleaning iron from everywhere in the body. I would take vitamin E over IP6 as an antioxidant, but would not reject IP6, as its iron removing properties are quite helpful. I especially think that young thals could benefit greatly by taking IP6 to help keep their pituitary gland free of iron.
I think B Complex has an important role, as there is a high turnover of nutrients in thals from the overactive bone marrow activity. I do think folate and B-12 should be supplemented beyond what is found in a B Complex supplement.