high ferritin level

Komal,

One Alpha  Leo is a special form of vitamin D called Alfacalcidol. This is used to treat hypercalcemia and is a special form of D used when parathyroid hormone production is low. I would trust the doctor to treat this condition. The tests scheduled are to test parathyroid hormone levels and also a clotting test (APTT). Your platelet count is low and this is the likely cause of your bruising. Please follow your doctor's recommendations, as he is trained to address these issues.

When I am on Exjade and my fe makes a real jump down...my platelets makes a big jump down too.
Is that also your case Komal?

Hi  Andy,
     Today i  got  the  results  of  PT  and  APTT
     TEST                            RESULT                   CONTROL
Prothrombin  time(PT)        10Sce                          10Sec
INR                                    1.0
 
APTT
Test                                  40Sec                          30Sec
 


TEST                         RESULT             UNIT         REF  RANGE
     

LFT
Bilirubin  Totall           2.3                     mg/dl        0-1.0mg/dl

Bilirubin direct           1.0                     mg/dl         0-0.25

Alkaline Phosphatase  348                     U/L            64-306

SGPT                     30                       U/L             0-36

After  seeing  the  reports  doctor  prescribed  further   tests.
1)  BLEADING  TIME
2)  ECHYMOSES  Platelet  count

He  said   take  Vit  C  tablet  of  500mg  but  i  think  dosage  is  very  high.am  very  confuse  because  of  these  blue  spots.
KOMAL
             
               

Hi Komal,

I really don't think you should take more than 250 mg vitamin C daily. The blue spots may be due to your ongoing low platelet problem and this is why your doctor is ordering these tests. This is related to liver function and your high iron along with hepatitis may be responsible for the low platelet level. Please continue to chelate daily, as this will also help control hepatitis.

Andy
        I  do  not  have  hepatits,  Hep  B  and  Hep  C  are  negative.yes  ferritin  level  is  high  am  not  taking  Asunra  since  10  days.
Am  really worried  is  the  problem  of  blue  spots  related  to  ITP??kindly  give  detail  answer  is  there  any  possibility  in  Thalassaemia.
komal

Komal,

Below is a photo of what ITP looks like on the skin. Your doctor is running these tests to determine how serious the slow clotting problem is. Prednisone is often used as the first treatment. If it's a severe problem that doesn't respond to prednisone, splenectomy might be the recommended solution. How long have you had this problem and do you know if you were sick before it started? ITP has been associated with Human Parvovirus B-19 (Fifth disease) and also to insect borne diseases. If there is any possibility of this, it might be wise to be tested for Human Parvovirus B-19 before deciding on the treatment.

http://www.nhlbi.nih.gov/health/dci/Diseases/Itp/ITP_WhatIs.html

hi
komal
i m from lahore and in our thal centre (ganga ram) many patients are on combination therapy of asunra+desferal then why your doctor is reluctant to advise u this.
if you have problem with this combination then you should try ferriprox+desferal and it is very effective and i am using this and i have brought me fe level from 11000 mg to about 800 mg. in the begginning you should take desferal 24 hours means every day by pump or iv...
it will take time but u shoul make right decision at that time and ask properly by your doctor and ofcourse he will guide u more better..

Andy
     Today  i  went  for  Bleeding  time  test  and  total  time  to  stop  bleeding  is  10min 10 Sec.
My  hemo  is  not  interested   for  further  test  he  said  you  have  history  of  low  platelet  count.
I  just  have  5to6   tiny   reddish   spots   on  legs    as  shown  in  picture  which  you  send  me  big  blue  spot  near  knee  has  remove  now.one  more  thing  I  do  not  have  these  bruises  continuously  they  just  appear  in  6  or  7  months.I  was  not  sick  before  this.
komal

Komal,

The good news is that your clotting tests show that this is not a serious problem. My suggestion is just continue with your normal treatment routine and always chelate as much as possible. High iron leads to so many different problems, and the only way to combat this is to lower your iron load.

Andy,
 
You  are  great  you  release  my  tension  how  much  I  was  worried   about  this.Definitely  i  will  continue  chelation  as  much  as  possible and  other  medicines.
Komal

Hi  Andy,
         I   am  on  Iv  desferal  these  days,its  second  time  I  have  abdominal   pain  its  mostly  occur  after  5 or  6  hours  of  chelation   mainly  after  having  meal.Before   this   I  have   same problem  but  not  after  every meal  as  happening  now.Am  using   6  vials  of  desferal.
Komal     
 

Dear Friends

I m patient of major thalasssemia  if u don’t mind I m asking some about some problems
   
Friends  my iron level is 5530 ng/ml  and I was using exjade tablets 20000mg per day from 16

months  my weight is 56kg and my HCV is positive my ALT(SGPT) is 400 U/l

My doctor was advise me about Desferal and Ferriprox combination he says leave exjad and start this combination .
I was start my therapy butt my subcutaneous sites  was swelling with deferral.

Before 2 year my subcutaneous therapy good is butt now i have very pain and very bad swelling the site is become red rashes .
Because my skin is very  thick and fat I m using thalaset 10mm butt that is not working

Cane give me some advise about my subcutaneous problem.

Because I m very worry for my iron   

When I had it that why I couldnt bend anymore.
Later when I had it by IV I had also problems. The guess was that the fluid contain way too much desferal. You might try to lessen the dosage of desferal.

Diluting the desferal with more water also does help. If you take the same amount of desferal over a longer period with more water, it actually does more chelation.

Hi Andy and  Dori

My dose is  2.5g Desferal in 25ml of  water

First I make 1g desferal in 10 water ml for 7 hours and then I make 1.5g in 15ml water for 9 hours