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some of 100% gooood news New bone marrow transplant method eases risk

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Offline 7assan

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some of 100% gooood news New bone marrow transplant method eases risk
« on: June 03, 2010, 01:36:19 PM »
WASHINGTON - Bone marrow transplants are undergoing a quiet revolution: No longer just for cancer, research is under way to ease the risks so they can target more people with diseases from sickle cell to deadly metabolic disorders.

The old way: High doses of radiation and chemotherapy wipe out a patient's own bone marrow before someone else's is infused to replace it, hopefully before infection strikes.

The new way: Rather than destroying the patient's bone marrow, just tamp it down enough to make space for the donated marrow to squeeze in alongside and a sort of twin immune system takes root. It's what doctors taking a page from mythology call "mixed-cell chimerism" — patient and donor blood and immune cells living together to improve health.


http://www.msnbc.msn.com/id/37068859/ns/health-health_care/
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #1 on: June 03, 2010, 01:43:27 PM »
WASHINGTON (AP) — Bone marrow transplants are undergoing a quiet revolution: No longer just for cancer, research is underway to ease the risks so they can target more people with diseases from sickle cell to deadly metabolic disorders.
The old way: High doses of radiation and chemotherapy wipe out a patient's own bone marrow before someone else's is infused to replace it, hopefully before infection strikes.

The new way: Rather than destroying the patient's bone marrow, just tamp it down enough to make space for the donated marrow to squeeze in alongside and a sort of twin immune system takes root. It's what doctors taking a page from mythology call "mixed-cell chimerism" — patient and donor blood and immune cells living together to improve health.


BONE MARROW: Lawsuit urges payment for donors

To find the best methods for these less intense transplants, different mixes of low-dose radiation and immune-suppressing drugs are under study at hospitals around the country.

But the ultimate quest is to allow transplants even when donors aren't a good genetic match, says Dr. Suzanne Ildstad of the University of Louisville— whose technique involves an experimental tweaking of donated cells to help them grow better.

"It makes it possible for anyone who has a mom or dad willing to donate marrow to them to have a transplant," says Ildstad, who has families with sickle cell and other childhood genetic illnesses lining up to try.

Separately, several hospitals are testing how to combine kidney transplants with bone marrow transplants from the same donor, in hopes that a hybrid immune system lessens the need for lifelong anti-rejection drugs.

"People are watching with eager expectation," says Dr. Lakshmanan Krishnamurti of Children's Hospital of Pittsburgh, who is helping to plan a multi-hospital study of some of the new methods for hard-to-treat adults with sickle cell disease.

Doctors have long known that a traditional bone marrow transplant can cure young children of sickle cell — if they have a well-matched donor. New marrow produces healthy red blood cells to replace the sickle-shaped ones that can't squeeze through small blood vessels, the cause of the disease's pain, infections and life-threatening organ damage.

But only about 17% of children have a suitable donor, usually a healthy sibling. Attempts to transplant adults have failed, their bodies too ravaged from years of the disease. Another hurdle: Certain immune cells in donated marrow sometimes become too aggressive and attack the recipient, called graft-versus-host disease or GVHD.

Enter the new research.

First came a tantalizing success in severely ill adults. Nine of 10 patients who underwent a less intense transplant — using low-dose radiation and two drugs to inhibit problem immune reactions — had their sickle cell apparently eliminated, Dr. John Tisdale and colleagues at the National Institutes of Health reported in December. They developed a hybrid immunity that produces normal red blood cells with no GVHD.

But those people had perfectly matched donor cells provided by healthy siblings. Few patients do.

Back in Louisville, Ildstad gives donated marrow a boost to try to overcome that problem while avoiding GVHD, a risk that worsens with mismatched donors. She removes troublesome immune cells from the donated infusion, leaving concentrated amounts of the blood-producing stem cells patients need plus "facilitating cells" that she discovered seem to help them take root.

In an NIH-funded experiment at Louisville and Duke University, the method so far worked in two children with sickle cell who had well-matched donors and one of four with a half-match.

Dr. Joseph Leventhal of Northwestern University gave an Ildstad-treated stem cell infusion to a handful of kidney transplant recipients who developed hybrid immune systems that seem to be holding nearly a year later. The first three treated are using one anti-rejection drug instead of the usual cocktail, and one soon will attempt full weaning.

"We're doing this in patients where it could have potentially the biggest impact," those with unrelated donors, says Leventhal, who anticipates giving one patient a month the dual transplant as the study continues at Northwestern Memorial Hospital.

The attraction to families: "You don't die from the new way," is how Bob Evanosky of Aurora, Ill., puts it.

His three sons have a devastating metabolic disease called metachromatic leukodystrophy, or MLD. Last summer, son John got an experimental outpatient transplant at Duke — a far cry from the months his brother Jack had to spend in intensive care after a well-matched transplant the old-fashioned way.

Dad was John's donor even though he's only a half-match — and the new cells are making the enzyme his body had lacked, too late to reverse the brain damage that has paralyzed the 8-year-old but perhaps able to ease some complications, says Evanosky, who plans to donate to his John's twin Christopher this fall.

Copyright 2010 The Associated Press. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.
http://www.usatoday.com/news/health/2010-05-10-bone-marrow_N.htm
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #2 on: June 03, 2010, 02:04:20 PM »
Bone marrow is in flat bones like the breast bone, hip bone, skull, ribs, and shoulder blades and at the ends of the femur (upper leg bone) and humerus (upper arm bone). It contains stem cells that produce red and white blood cells, blood vessels and several other types of cells.

The standard bone marrow transplant requires that a person’s bone marrow be completely wiped out before the donor’s marrow is put in. This period of time when the person has no immune system can be deadly if they get an infection. But bone marrow transplants cure children of sickle cell anemia and are used to treat cancer patients and those with metabolic disorders.

What doctors are doing is partially destroying the recipient’s bone marrow and adding the donor’s so the patient develops a hybrid immune system, a combination of theirs and the recipient’s. Doctors refer to it as “mixed-cell chimerism.”

There are two problems that doctor hope this new technique will overcome. One is finding a suitable match. Only 17 percent of kids with sickle cell anemia have a match, most likely a healthy sibling. Adults with sickle cell anemia do not respond well to bone marrow transplants. The second is that immune cells from the donor can end up attacking the recipient, a phenomenon called “graft-versus-host disease,” of GVHD.

Several studies have already demonstrated success with this technique. In one study with two children, one with a well-matched donor and the other with a half-match received bone marrow that had the cells implicated in GVHD removed before receiving the transplant. Both are doing well.

A study was done in which 9 adults with sickle cell anemia who were severely ill had low dose radiation and two immunosuppressant drugs before receiving bone marrow no longer suffer from the disease and did not experience GVHD. They did developed a hybrid immune system.

This technique may also be useful for those receiving organ transplants. A study in which four kidney transplant recipients who have hybrid immune systems through this technique are only taking one immunosuppressant drug rather than the cocktail that is normally prescribed.

Hospitals involved in this research are using different combinations of low-dose radiation and immunosuppressant drugs to determine how to achieve the best results

http://indyposted.com/22043/new-bone-marrow-transplant-technique-allows-for-less-than-perfect-match/
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Offline Zaini

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #3 on: June 03, 2010, 03:57:05 PM »
Thanks for sharing Baloch.

Zaini.
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #4 on: June 03, 2010, 05:04:36 PM »
it,s ok any time
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Offline Dori

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #5 on: June 03, 2010, 06:35:20 PM »
You know me all, I haven't read it all. Simple hasn't any time left to do it.
Won't those two systems start fighting with eachother
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #6 on: June 03, 2010, 07:12:13 PM »
Enter the new research. First came a tantalizing success in severely ill adults. Nine of 10 patients who underwent a less-intense transplant had their sickle cell apparently eliminated. They developed a hybrid immunity that produces normal red blood cells. Those people had perfectly matched donor cells provided by healthy siblings, but few patients do.
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Offline Dori

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #7 on: June 03, 2010, 08:16:23 PM »
I have heard of this before. About scd and mini-transplants
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #8 on: June 03, 2010, 08:22:05 PM »
The linke in the up is from health news web site wich is the date 15 may 2010 i think so
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #9 on: June 03, 2010, 08:27:44 PM »
The new way: Rather than destroying the patient's bone marrow, just tamp it down enough to make space for the donated marrow to squeeze in alongside and a sort of twin immune system takes root. It's what doctors taking a page from mythology call "mixed-cell chimerism" — patient and donor blood and immune cells living together to improve health.
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Offline Andy Battaglia

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #10 on: June 03, 2010, 09:23:31 PM »
Yes, mixed chimerism does work, as previously noted in the thread at http://www.thalassemiapatientsandfriends.com/index.php?topic=2704.msg25654#msg25654

Dr Krishnmaurti has been a leader in this work of finding a gentler way to do BMT. We are seeing this same difference in approach between the two different gene therapy groups and this is one of the reasons I much prefer Dr Sadelain's approach.
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Offline Sharmin

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #11 on: June 04, 2010, 05:10:29 AM »
Andy,

This is all very exciting.  We were lucky to hear some of these developments in New York. 

Have you heard anything more about Dr. Sadelaine's research and the clinical trials?

Thanks Andy,

Sharmin
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Offline Andy Battaglia

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #12 on: June 04, 2010, 05:30:36 AM »
I recently received this message from Pat Girondi.
Quote
Dear Andy,
 
I am sorry that i have not communicated lately.
 
I also want to apologize for the lateness in the project.
 
Michel, Isabelle and team will submit the IND by June 30th. We should be in patients in September.
 
Give my love to all of rocco's brothers and sisters. [Rocco is Pat's son. Rocco has thal major].
 
I am presently in India looking ahead. India has at least 200,000 of our brothers and sisters and certain experts estimate the population over 500,000.
 
I know that all of us live for this dream. A dream that would not have been possible without Michel Sadelain, Isabelle Riviere. Chris Ballas, Norb Weich, Jason Feldman, Sam Salman, kostas Antypas, Joe Feldman, Enrico Colucci, Vito Cirrottola, Giuseppe Schmidt, Paritosh Landahni, Teddy Jimbob Beechcroft, Georgey Hanley, Adrian Herzog, Aurelio Maggio, Angela Iacono, Renzo Galanello, Renzo Arbore, Onofrio Pepe, Mauro Bove, Franco Locatelli, Ron Capano, John Sion, Jonathon Ascoff, Alessandro Contessa, Billy boy Mc Cluskey, Mark Step, the Bucellatos,  Derek Holmes, Derek Persons,  Angela Chen,  Sharon Carsten, Greg Swan, Charles Columbus, Susan Agnelli (late), Steve Petrosky John Walton (late) Mike Ahearn, Hsuan Hargest...
 
Frankly, I could never finish thanking all of the many people and there are no guarantees that the trials will go well. The drug Thalagen looks great in the sick cells treated thus far.
 
As you know we have done the the stem cell mobilization in patients already thanks to the support of Dr George Stam.
 
Please continue to send your love.
 
I'll end on a funny note.
 
Recently we were looking around for some cake. I told Jason to check the Orphan Dream acct. The Orphan Dream acct. Gets the money for the music.
 
Recently, Focaccia Blues the second most popular film from italy used our two songs 'Flim Flam Man' and 'It's Your Time'. The film is now at Cannes and won the Golden Globe Award.
 
Anyway, we needed cake for the final payment of the vector. Jason checked the OD account to find 8,000.
 
Wow!!! The bad taste in music by so many is wonderful.
 
This year at Gateway the Capano family and their fantastic friends hold a golf outing for the Cooleys' Intl (not to be confused with the foundation). To date the Cooly's Intl have invested 100,s of thousands for us.
 
Last year at the even Ron, Flo, Gina and gang dished over 200k.
 
This year I'm going to tell them that I'll do a performance... They may just send a check without telling me the date.
 
Excuse me for all of the people that I did not mention. The list would be 10 times longer.
 
We now have 3 pharma companies looking at the project and as always we need help. My favorite is Sigma Tau. Write gregg Lapointe and thank him for their past support and tell them how much you appreciate them considering to help us further.
 
gregg.lapointe@sigmatau.com
 
Sigma T is our kind of people.
 
Ok my brother Andy. Get the message out!
 
September!!!
 
All we need is a little gene expression of the beta globin gene and they'll be knocking the doors down to help us...
 
Pat g
Sent from my BlackBerry® wireless handheld

I loved that last note about the funds. We do make a difference by purchasing Pat's music. Go to http://www.cdbaby.com/Search/cGF0IGdpcm9uZGk%3d/0 to buy his CDS or download his music. All proceeds go to help fund gene therapy. Tell your friends. It's a cheap and easy way to help out. The only obstacle to success is money. Let's do everything we can to spread the word. For Pat. For my new Facebook friend, his son Rocco. For all of you. Let's get this done.
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #13 on: June 04, 2010, 07:27:51 AM »
Thanx for the update but the new way is allready don for 10 adults . so that mine adults can do bmt and the chanc going up day by day
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Offline 7assan

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Re: some of 100% gooood news New bone marrow transplant method eases risk
« Reply #14 on: June 04, 2010, 04:28:47 PM »
dear andy mixed chimerism is befor bmt or after bmt and bmt done with out High doses of radiation and chemotherapy......?
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