The small changes in Hb and ferritin are not significant and cannot be assumed to be related to the use of curcumin, but are what is normally expected when testing is done from month to month. One must remember that these levels are affected by many factors, including the limits of testing itself and that small changes have no relevance. The real value in this study is that it shows the powerful antioxidant effect of curcumin in red blood cells. The value is not a rise in hemoglobin, but a slowing in the drop of hemoglobin, because curcumin is protecting the red blood cells from early hemolysis, which means that red blood cells should live longer when curcumin is taken regularly. This would hopefully be reflected in a reduction of the frequency of transfusion.