It has been 4 months since we started Exjade on our 3 year old. I have been amazed by the results. My son's liver and spleen are noticeably smaller. (Drs confirmed that too). We noticed that just about 2 months into Exjade. We started at 10mg/kg and increased to 20mg/kg after 2 months. Ferritin isn't accurate measure of iron deposit, it's just a guide. 2 months after we started, Adel's ferritin level shot up to 2,000, we started at 1,200 (?) It's his general well being that we are impressed, he was previously breathless and rather dependent on O2, now, he's running around like he doesn't need any O2. We are weaning down his O2 to an incredibly low level. We even went out sometimes without the need of O2, but we just carry it along in case he needs it. Incidentally, Adel's on Zantac too, he's been scoped by ENT recently for other issues and has been prescribed Zantac due to reflux. It could be Exjade causing reflux? I'm glad I started Exjade and I ask now, why did I not start Exjade sooner? Yes, hydration is important, notice the change of colour of urine from brownish to normal, if given consistently. I give green tea, by encouraging him to take sips so often. That's my experience with Exjade.