Assessment of Puberty in Relation to L-carnitine & Hormonal Replacement Therapy

This is some extremely important research with great relevance to thalassemics in puberty or approaching puberty, with special significance to those who have delayed puberty. L-carnitine appears to play an important role in the normal sexual development of thalassemia patients. Since we alreay are aware of the importance of L-carnitine to heart function and the prevention of pulmonary hypertension, I feel that we really need to emphasize exactly how important this nutrient is to all thalassemics. Again we see the name of our friend, Dr Amal El Beshlawy as the head researcher.

http://tropej.oxfordjournals.org/cgi/content/full/fmn043v1

...Improvement of pubertal staging was observed in 50% of males after L-carnitine therapy compared to 75% of them after hormonal therapy. While improvement of pubertal staging was seen in 90% of females after L-carnitine therapy compared to 100% of females after hormonal treatment. However, these results showed no significant difference between both groups. The interval between consecutive blood transfusion in weeks had a significant increase after L-carnitine treatment (p-value = 0.05*).

Hormonal treatment yielded higher results, but the effect of taking L-carntine alone cannot be disputed. This can be an important nutrient in developing thals. I think the last sentence is also of great relevance.

Dr Beshlawy has previously brought us the findings relating to L-carntine and heart function in thals. http://content.karger.com/ProdukteDB/produkte.asp?Doi=76522

Hi Andy,
this information is really usefull.my daughter firdaus is now13 yr old(thal major) and she shows no signs of puberty so far.her height doesnt seem to increase as well.Do u think i shld put her on this treatment.please tell me how do i start...thanks so much.
Marziya
This is some extremely important research with great relevance to thalassemics in puberty or approaching puberty, with special significance to those who have delayed puberty. L-carnitine appears to play an important role in the normal sexual development of thalassemia patients. Since we alreay are aware of the importance of L-carnitine to heart function and the prevention of pulmonary hypertension, I feel that we really need to emphasize exactly how important this nutrient is to all thalassemics. Again we see the name of our friend, Dr Amal El Beshlawy as the head researcher.

http://tropej.oxfordjournals.org/cgi/content/full/fmn043v1

Hormonal treatment yielded higher results, but the effect of taking L-carntine alone cannot be disputed. This can be an important nutrient in developing thals. I think the last sentence is also of great relevance.

Dr Beshlawy has previously brought us the findings relating to L-carntine and heart function in thals. http://content.karger.com/ProdukteDB/produkte.asp?Doi=76522
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Hi Marziya,

You should talk to the doctor where your daughter is treated about starting hormonal replacement therapy. It is essential to start young, as waiting to the older teens yields lesser results. I would also suggest that she does take L-carnitine supplements. This needs to be addressed early on.