1- I was just wondering does the excess beta chains in HB H (alpha thal) have the same bad effect in terms of oxidative stress as the excess alpha chains in beta thal intermedia?
2- When hydroxurea is given to beta thal, the purpose is to make the gamma chains combine with the excess alpha chains in order to produce fetal hb. What I can not understand is that why hydroxurea is sometimes given to HB H patients. They don't have enough alpha chains in the first place, so to what will the gamma chains combine with?
Manal