Hello all,
As most of you know serum B12 level ranges in most countries are very low and are unable to detect sub-clinical B12 deficiencies. Many studies and doctors suggest that B12 serum levels need to be >450, yet you can find lab ranges as low as 170, while Japan has the bottom range at 550. Thus, many B12 sub-clinical deficiencies remain undetected. Thalassemia minors need more B12 due to the higher RBC turnover plus they are more likely to have some additional health issues that can hinder absorption. Thalassemia minor additionally masks B12 deficiency which generally eads to macrocytic anemia.
I wanted to bring your attention to this case study as it relates to B12 and thalassemia minor.
http://www.actaneurologica.be/acta/download/2004-4/07-Bilic.pdfPlease regularly supplement with B12 and check your serum B12 against reasonable lab ranges, check homocysteine, and methylmalonic acid as well when in doubt.