Blood Transfusion by John Porter

From John Porter Blood Transfusion (The entire PowerPoint presentation is attached to this post).

Recommendations complicated by the use of different anticoagulant-preservative solutions.
For CPD-A units with a haematocrit of approximately 75%, the volume per transfusion is usually 10-15 ml/kg, administered over 3-4 hours.
Units with additive solutions may have haematocrits of 60-70%, and therefore larger volumes are needed to administer the same red cell mass as delivered by CPD-A units with a higher haematocrit
For most patients, it is usually easier to avoid these differences in red cell concentration by ordering a certain number of units (e.g. 1 or 2) rather than a particular volume of blood.
Younger children may require a fraction of a unit to avoid under- or over-transfusion.
Patients with cardiac failure or very low initial haemoglobin levels should receive smaller amounts of red cells at slower rates of infusion.

Dear Andy,

What is the formula used when calculating the amount of blood that a patient receives in order to maintain an acceptable Hb level ?

Also, what is the difference between Leukocyte depleted and Leukocyte poor blood ?

Thank you and Best regards,
Shastri & Alicia.

Hi Andy,

I am new to the forum! Thank you for accepting me. Reading Prof Porter blood transfusion requirements presentation , made me a bit confused, at one point he states:
Evidence that maintenance of higher hemoglobin levels does require more blood .

–transfusion requirements of 14 French patients were directly proportional to  mean Hb and nearly doubled between 9.6 and 13.4 g/dL (Brunengo 1986 ) etc

Any input on this? My believe was that if hb is high you receive less units of blood  consequently if low hb, more units?

It requires more blood initially to reach an Hb goal, but after that it should not, unless some factor like an antibody reaction is causing the blood to be destroyed faster. I don't know of any patients kept at an Hb above 11, so it may require more blood if an Hb >12 is the goal, although that seems to be an unrealistic goal.

Thank you, Andy:)
 I am going to ask Prof Porter as well at our next appt .
xxx

Another excellant article. Thank you Andy for sharing.

I have just read the whole document but i need help in understanding some of it...