It is difficult to get a child to take wheatgrass juice, as the taste is much like mowed grass. Wheatgrass tablets are preferred. If wheatgrass extract is available, it is the easiest method of taking it. The folic acid appears to be helping. I would like to see if the retic count stays low, as this will eventually have a positive effect on spleen size. Yes, hydroxyurea does cause the spleen to shrink, as it reduces the amount of ineffective red cell production. However, because a significant drop in retic count has been noted, I would suggest waiting and see if this is sustained, as the spleen will begin to shrink if less bad RBCs are produced. Some members here have mentioned herbal preparations that affect spleen size, but I am not familiar with them. perhaps we can get some input from those more familiar with the herbal remedies.