Continuous issues with Exjade.

I was feeling little good than yesterday when I woke up. However when two hours back I took IP6, I don't know if it's my doubt or just misconception but I'm feeling slight burning and pain again.

Andy,

I've read somewhere that IP6 should not be taken who has liver disease (as in my case, I don't have one, but maybe having little high SGPT may lead IP6 to cause some problems?). So I plan to stop IP6 till I heal myself completely.

What do you think?

-P.

Hi everybody,

My sonography reports has arrived.

It's a good news that there's nothing major, spleen is enlarged (didn't mentioned how much) but that's normal for thals, and the liver is slightly enlarged as well (I think majors has slightly enlarged liver anyway? Please correct me if I'm wrong). My kidneys are normal as well, and I think there is no appendix or stomach problem (if there was, it should indicate in USG for abdomen right?)

The physician went off to home so we could not get him sonography reports checked, so will do that tomorrow.

I'm attaching the report.

-P.

After extensive searching, I can say that there are absolutely no known side effects even for huge doses of IP6. However, I finally found some info about the initial side effects some people experience when starting IP6.
http://www.livestrong.com/article/390116-ip6-inositol-side-effects/

Diarrhea
IP6 inositol may induce a problem in your bowels temporarily that disturbs the normal balance of digestion, Sloan-Kettering states. This can produce watery stools, also known as diarrhea. This non-serious side effect may cause cramping in your abdomen, but should recede and stop as your body adjusts to IP6 inositol. If your diarrhea appears severe or does not stop in a few days, see your doctor.
Flatulence
When you begin using IP6, you may develop more gas in your intestines than normal, Sloan-Kettering indicates. This can produce flatulence. This side effect of IP6 does classify as a non-serious health concern and should desist once your body has made the appropriate adjustment to the supplement.
Nausea
Because IP6 inositol hexakisphosphate can cause disturbances in your gastrointestinal system, you may feel queasy when you begin using it. Nausea may occur as a mild side effect and should cease on its own in a few days. If it causes vomiting and feels severe, see your doctor for help

My advice is to begin again with just one capsule daily. See if the symptoms clear up. Your reports are all good, so it is unlikely anything serious is going on. One other thing I learned was that IP6 works even better when taken with inositol.

Another note I want to make is that IP6 can inhibit absorption of minerals, so it shouldn't be taken with meals. But to correct a misunderstanding many people have about IP6, it will not cause mineral deficiencies. The human body has regulatory mechanisms that should be trusted.

After extensive searching, I can say that there are absolutely no known side effects even for huge doses of IP6. However, I finally found some info about the initial side effects some people experience when starting IP6.
http://www.livestrong.com/article/390116-ip6-inositol-side-effects/
My advice is to begin again with just one capsule daily. See if the symptoms clear up. Your reports are all good, so it is unlikely anything serious is going on. One other thing I learned was that IP6 works even better when taken with inositol.

Another note I want to make is that IP6 can inhibit absorption of minerals, so it shouldn't be taken with meals. But to correct a misunderstanding many people have about IP6, it will not cause mineral deficiencies. The human body has regulatory mechanisms that should be trusted.

Thank you very much Andy.

I think I'll start it now when I'm completely healed with my pain. I'm getting worried because I just had transfusion on Saturday and Exjade is stopped since almost a week (completely!).

What about liver enlargement? Is it normal? Can it be swelling? If so can it be reduced with proper medications or such?

-P.

Pratik,

Liver and spleen enlargement are common in thals and are a result of the breakdown of the transfused blood. Nothing to be concerned about as long as the spleen doesn't become huge.

Pratik,

Liver and spleen enlargement are common in thals and are a result of the breakdown of the transfused blood. Nothing to be concerned about as long as the spleen doesn't become huge.

Thanks Andy.

I think my spleen is being good. This time my Hb was 9.9 which is unbelievable. Although I was expecting around 9.2 or 9.3 but not 9.9! I think it's result of IP6.

Hopefully I'll start IP6 again when my liver is completely healed. I am showing some improvement today and I think I might be able to start Exjade in 2-3 days.

-P.

Hi everybody,

My sonography reports has arrived.

It's a good news that there's nothing major, spleen is enlarged (didn't mentioned how much) but that's normal for thals, and the liver is slightly enlarged as well (I think majors has slightly enlarged liver anyway? Please correct me if I'm wrong). My kidneys are normal as well, and I think there is no appendix or stomach problem (if there was, it should indicate in USG for abdomen right?)

The physician went off to home so we could not get him sonography reports checked, so will do that tomorrow.

I'm attaching the report.

-P.

Good to see good report, Pratik.

Whenever u go for Sonography do ask the doc. for exact size of spleen in cms.
because they generally don't give it in the report.

Good to see good report, Pratik.

Whenever u go for Sonography do ask the doc. for exact size of spleen in cms.
because they generally don't give it in the report.

Yea, I just got to know during this reports. Is there a way I can know now from reports or contacting the sonography center to tell me it's size without performing another sonography?

-P.

Hi everybody,

I've started with 1/4th of my dose from today (400mg; 1600 was regular) and would going on boosting the dose to 1600 during these 4-5 days. Hopefully now it won't matter me again.

Iron, here I come to fight with you!

-P.

Yea, I just got to know during this reports. Is there a way I can know now from reports or contacting the sonography center to tell me it's size without performing another sonography?

-P.

Yes ,
go to the centre with your report

tell them that your doc has asked for exact size

if the data have been saved in their sono machine they will give you new print

u can ask an image / photo also

I again started Exjade today and am having liver sided pain, this is now irritating me. I only took 400mg (1/4th of my dose) today.

Plz do CBC report and check platlate and wbc counts.

Pain might be due to spleen.

Plz do CBC report and check platlate and wbc counts.

Pain might be due to spleen.

I always get that done. Both are normal.

And I'm experiencing pain near lower middle right side, near the liver. My Hb stays fine too so spleen would be good I believe.

-P.

I'm wondering if the gallbladder might be involved. Have your bilirubin reports been normal?

I'm wondering if the gallbladder might be involved. Have your bilirubin reports been normal?

Yes Andy, they were normal.

My physician feels as if it might be a little swelling or a muscle spasm and he has prescribed me a tablet 2 days back and I'm taking it. Slight improvement is noticed. It's really shaky to come to a conclusion as on one point I might feel good and some other time, it again disturbs me.

But I noticed one thing that when my sugar levels are normal, it pains less or that's just me. I'm trying very hard to keep my sugar levels normal.

And moreover, if there was something wrong in gallbladder wouldn't sonography tell it?

-P.