Early Detection of Response to Hydroxyurea

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Offline Andy Battaglia

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Early Detection of Response to Hydroxyurea
« on: May 28, 2011, 07:07:27 PM »
http://informahealthcare.com/doi/abs/10.3109/03630269.2010.513638

Quote
Red blood cells (RBC) and reticulocyte parameters were determined on peripheral blood from a subset of patients enrolled in the multicenter study of hydroxyuea (HU) in sickle cell anemia. Multiple blood samples were obtained every 2 weeks. Cellular indices were measured by flow cytometry. Generalized linear models were used to determine the relationship between the longitudinal trajectories of RBC and reticulocyte indices and HU usage. There was a significant relationship between HU usage and most of the RBC and reticulocyte indices. Hydroxyurea produced higher value trajectories than those generated by placebo usage for the hemoglobin (Hb) content of both the RBCs and reticulocytes and for the mean corpuscular volume (MCV) of reticulocytes. These changes were first detected 10 weeks after starting HU and before the increase in Hb F levels. The data suggest that subtle and early markers of response to HU reside in the hemogram.


Read More: http://informahealthcare.com/doi/abs/10.3109/03630269.2010.513638

This was a study of sickle cell patients, but should also be applicable to thalassemia. These early tests are good indicators of the usefulness of hydroxyurea in thal patients, also.
Andy

All we are saying is give thals a chance.

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Offline Manal

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Re: Early Detection of Response to Hydroxyurea
« Reply #1 on: May 28, 2011, 11:13:50 PM »
Yes this is exactly what happened to us from the first month of using hydrea.  Increase in MCV and hematocrit and decrease in the reticulocyte counts


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Offline Dharmesh

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Re: Early Detection of Response to Hydroxyurea
« Reply #3 on: May 25, 2013, 06:46:20 AM »
But it do not show the results... ???
Start listening your body, it always gives signs

 

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