Hardik

Hello Everyone.....

As i observed that whenever i gave ip6 to hardik his sgot and sgpt start increasing.Earlier when his sgot /sgpt reaches 160/427 ..in Jan 2016...... I stopped desirox and ip6 for a month to get the values back to normal which took around a month ....and then firstly i started only desirox ,....not ip6. ...values remain same as last tested and then i slowly add on ip6 on alternate days ....his sgpt and sgot again increased to 160/143 .....and he had swelled eyes .....everytime...when liver values changed.

.. .....Is it possible that intake of IP6(510 mg) by 2 and half child weighing 12 kg shows adverse effects on SGOT and SGPT.....and increases it beyond original values by 3-4 times.

And one more question is:---

My. Mother 's blood always remain at 6(I think she is Thal minor and I m inherited from her but she refused to test) and is not increasing from past 2 years .She is around 55-60 of age....and now her health is refusing to favour her....and cause severe pain in all joints especially knee joints,weight is increasing day by day instead of cycling ,exercise and walking ...

Plz guide about hardik and what to do to increase her blood levels ....and energy too...can she take IP6......plz tell
What to do for her good health

Plz reply

Hardik,

Increased LFT's would be more likely because of desirox than ip6. You can see by dividing desirox dose if it helps. Also, for such a young child with not so high ferritin, it really needs to be seen whether desirox dose is absolute necessary at this point or not. Usually, there is some room to pause chelation for a while in very young children. You should include wheatgrass in her diet as it may prove very beneficial in your case. I would be focusing more on ip6 and wheatgrass at this point than forcing desirox to work.

As for your mother, low Hb do cause joint pains, wheatgrass can increase energy levels when Hb is low. Anyone can take ip6 so there's nothing wrong in that. Calcium and Vitamin D tests can also be done to see if there are deficiencies, as they are very common in women as they age.

Hello waheed
Thanks for reply
But his(weighing 12 kg) ferritin is very high 2131....and I m givving him only 250mg right now ....due to high liver vàlues and thats on alternate dates....feeding him with plenty of water......and Wheatgrass also.......even then these values making me so much worried for his health ......plz guide

Have you tried milk thistle?

It is the general observation that Desirox brand increases the LFTs more in thals than other brands

Hello thalpals
Thanks for reply.....

Kk if I stop desirox right now for 10 days ......then is it possible that giving him only IP6 ...and Wheatgrass.... Can help to reduce ferritin and lowering his lft values as I have to go on 30 of this month to hospital..... So then I can talk to doc about his health factors..

And plz also mention better alternative to desirox.


Thanks
Neha

Yes, you should take a break from the chelation to get the liver scores back to normal. After the break, introduce the drug back slowly, taking the dose every other day for two weeks and check the liver scores. Make sure the test is done early in the day when the liver score is lower and that the child is well hydrated for the test. If it's back to normal, resume daily chelation. Continue the IP6 and wheatgrass throughout.

Tab Defrijet (Sun pharma) and Tab Asunra (Novartis) are another brands.

Hello Andy

It's so frustrating when you know the fault and can't repair it......The same is happening to me..
Hardik's serum ferritin always shows near about 2000 value...as he is on desirox 250 mg(2.8 year,13 kg) and moreover desirox doesn't suit him anyway....and always increases his Lft (latest sgot/sgpt are 70/122) when this time I tried to increase the dose by half ...(on my risk).
I tried split dose(1/2 morning but not empty stomach. ,IP6 and Wheatgrass in afternoon after 6 hours gap and 1 tab of desirox in night again after 6 hours gap)  ....but that doesn't work also. The only hope is Wheatgrass (3 grms)and IP6(1cap-510 mg). It's almost about 1 yr that doc had started his desirox but no sign of iron removal till now..(no black stool) and moreover now the baby screams for stomach ache daily(may be effect of iron)..though I gave him plenty of water...but the doc ....ohh their attitude...and .... thoughts that she knows everything is so unbearable........and the best part ...single hametologist....with not listening attitude makes it worst.What to do...?where to go??? Don't know

Guide about....
1)which milk thistle to buy ,when to give and how much quantity for baby .
2) which chelation to adopt and how to start without doc advice.
3)what to do for stomach ache.
4)can lack of folic acid cause stomach ache? As I gave 5 mg on alternate days.....can dis be the reason?

Hey Hardik,

Cool down everything will be all right.Where are you from?

Have you tried the desirox right after a meal? Any milk thistle supplement that is just milk thistle will suffice. There is also a supplement called Liv 52 which many find helpful for keeping down liver scores. The stomach ache is most likely due to the desirox, as that is a common side effect, and many patients deal with it by taking the drug right after a meal.
The scores are not high enough to consider stopping the drug, but I think with some trial and error, they will come down.

Hardik,

It takes time for S. ferritin to come down. It took more than two years to see a significant downward shifton our child when she first started chelation. The best way to know if the chelator is working or not is liver MRI.

for the stomach ache, try giving Zantac (Ranitidine) to your child. My daughter has significant stomach issues from using Exjade (even after taking Exjade with food, right after food, split dose and so on). so now she is on Zantac 75mg (twice a day - morning & evening) and the stomach issue is under control. Also we have seen that if she is eating every few hours (and drinking enough liquid) without a long gap between meals, the stomach issues are under control.

Your child is only 2.8 yrs age? if that is the case, In my opinion, don't feed him/her too many supplements. Just healthy meal at regular interval, lots of fluid, dose of ranitidine (to keep stomach ache under control), one multi-vitamin (iron free) and the chelation med. That will be enough.

I will suggest not to do any other chelation without doctor's advice. Just keep up the chelation with the right dose and get the side effects on Desirox under control. it will take time but it will work.

I am giving multivitamin polyvsol without iron 1 ml per day and folic acid with 5 ml of super shot wheatgrass.  I am exploring ugu leaves as it comes in dry and raw format.  Looking for a genuine source and retail company that sells authentic product. 
Also giving boiled organic egg

Thanks Parin , Bostonian_04, BabyRiya ,Andy and everyone here  for ur kind help.....

yes Andy , your advice works .....desirox after meal...and it works...no complaint from last one week..
but I had reduce the dose to 250mg again(half morning and half night) and the swelling under eyes gone(symptom of increased Lft in his case)...
I want to order milk thistle...so plz advice about mg /kg required for a 2.8 year baby weighing 13 kg .
On PuritanPride 250mg /100 cap are available and on amazon link given below...varieties are there....so which to prefer
Plz also guide about the dose of IP6 according to mg/kg as of now I m giving I cap of 510 mg daily

http://www.amazon.in/s/?ie=UTF8&keywords=milkthistle&tag=googinhydr1-21&index=aps&hvadid=123337664411&hvpos=1o2&hvnetw=g&hvrand=1696327924218720613&hvpone=&hvptwo=&hvqmt=b&hvdev=c&hvdvcmdl=&hvlocint=&hvlocphy=1007751&hvtargid=kwd-27400525268&ref=pd_sl_297z169zvo_b

Splitting the dose works better anyway, so it should be done.
250 mg milk thistle daily or every other day is sufficient at this age. The IP6 dose is also as high as it should be. If either IP6 or milk thistle causes any digestive issues, take every other day.
The brand shown in this link is excellent. Any brand like that which is simply milk thistle is best. Open one cap and mix with food or liquid. If you use this brand, take one every other day. http://www.amazon.in/Zenith-Nutrition-Silymarin-Thistle-Standardized/dp/B008L99WL0/ref=sr_1_3/256-0255141-7926214?ie=UTF8&qid=1471732956&sr=8-3&keywords=milkthistle