Hi Shilk,
A study of thal minor women concluded that thal minor women have no higher chance of miscarriage than non-thal women. So, every doctor will tell you that is the case. But the reports from thal minor women at this group and at the Facebook groups tell a different story. Many of these reports come to me as confidential messages, so others may not be aware of the high amount of thal minor women who have had miscarriages and how many have had multiple miscarriages. The doctors may not be aware of it, but I have heard so many reports of anywhere from 2-9 miscarriages among thal minor women, that I have to believe there is a connection, and because there is a known problem in the more serious forms of thalassemia, one could expect that some of the same things are going on in minors. There is a known issue called the hypercoagulable state that is often found in thal intermedia and major patients, and it leads to clotting in the blood. During pregnancy, this can cause a decrease in blood flow between the uterus and placenta, leading to miscarriage. This clotting is not normal clotting. It is due to the amount of "debris" in the blood in thalassemics. There is an overproduction of ineffective red blood cells and there are unmatched alpha globin chains, which are basically obstructions in the blood.
I would suggest that when you are pregnant, you raise the dose of L-methylfolate to 2-5 mg daily. This is important for the added demand for red blood cells during pregnancy. And take 400 IU natural vitamin E daily during pregnancy. Vitamin E is a powerful antioxidant and a natural blood thinner, which will help prevent the decrease in blood flow between placenta and uterus. A diet high in antioxidant foods and supplements can be of great value to those with thalassemia.
Don't let this get you too depressed. It happens a lot. Just take really good care of yourself and get great nutrition during pregnancy. We have a lot of nutritional advice for thal minors here that can be very helpful in maintaining good health.