Hi I need help, I am so confused!
My son's newborn screening came back as having Sickle Cell Anemia (SS). My husband and I both got a HPLC done and my husband's showed that he has the Sickle Trait but mine was negative for the Sickle trait but I had elevated A2 levels and slightly elevated Hgb F, suggesting Beta Thal Trait. When I showed the pediatric hematologist, him and the nurse basically said it was impossible that my son had a thal trait, but didn't explain why not and didn't really seem to know much about thalassemias. I'm currently searching for another hematologist but in the mean time I am trying to get as much info as I can.
My son's HPLC @ 9 weeks showed:
Fetal Hgb: >40.0%
Hgb A2: 1.0%
S Hgb: 16.2%
A Hgb: None
His Hemoglobin on his CBC was within normal range as well as his MCV. The only thing that was out of range was his RDW, which was High.
My HPLC showed:
Hgb A: 90.5%
Hgb A2: 5.9%
Fetal Hgb: 3.6%
My CBC shows low MCV, MCH and high RDW.
I understand the hematologist may be looking at my son's A2 levels, but what else could it be?