IVF often does not work on the first try. I feel that doctors should clearly explain this to prospective parents, so that they understand there is likely to be some disappointment and added expense involved. I feel that parents should know this so they can make a proper decision in advance, and that they should be prepared to try at least 2 or 3 times. My advice, is that if you can manage it financially and physically, that you should try at least one more time. I would also suggest that you take a high dose of folate daily, 5 mg L-methylfolate, while you are trying to get pregnant. This will have a positive effect on embryo attachment to the uterus.
Gene therapy is coming but it will be at least a 5 year wait before it is available, and we do not know if it will be able to free all thal majors from transfusion. Both companies involved in gene therapy for thalassemia are very confident that this will eventually work for thal majors. So, if you decide to wait, the outlook is quite good in the long term. Along with other treatments in development, I see a future where most patients will be freed from transfusions and I see that coming within the next 20 years.