Oestoporis and high ferrtin levels

Hi one of patient has severe orstoporis and high ferrtin levels & T2 * is severe in heart and liver .
What will be best chealtor to avoid bone problem
Thanks

Desferal would be the one to avoid most, but when the iron load is severe, desferal is a must, unless the patient can be on full doses of both oral chelators at the same time. High doses of vitamin D and B-12 will also be of help. I would also suggest a natural chelator, as even though they are much weaker than the drugs, they can access places two of the chelators can't at all and can protect vital glands and organs. IP6, green tea extract, turmeric capsules can all help. They are all also potent antioxidants, which will also help protect the organs.

I was told something this week about IP6 that was new to me. This patient is having low white blood cell issues. When he uses IP6, he has found they return to normal. I speculate that it is the antioxidant property of IP6 is preventing the white blood cells from being filtered out by the spleen.

Hi Andy, please can you explain why desferal is to be avoided regarding osteoporosis.

Thank you.

It's actually the toxicity of desferal in high doses that causes bone loss and poor bone growth. It is highly associated with use in patients before 3 years old and at does of over 60 mg/kg.

http://www.esh.org/files/doc/IRON2009_CAP.11(264-285).pdf

y. In regularly transfused
and well-chelated patients, deferoxamine at high doses or at therapeutic doses in
patients with hypersensitivity, can be toxic to osteogenesis, collagen synthesis and
bone turnover, leading to reduced growth (especially of the trunk), protrusion of the
sternum, valgus deformity of knees and elbows, swelling of wrists and knees and sliding
of the femoral head (27, 28).

So, once a week of  desferal, 2000mg, is okay...would that also effect bone health..

Once a week desferal shouldn't have an effect on bone growth.

Thank you Andy.

Desferal would be the one to avoid most, but when the iron load is severe, desferal is a must, unless the patient can be on full doses of both oral chelators at the same time. High doses of vitamin D and B-12 will also be of help. I would also suggest a natural chelator, as even though they are much weaker than the drugs, they can access places two of the chelators can't at all and can protect vital glands and organs. IP6, green tea extract, turmeric capsules can all help. They are all also potent antioxidants, which will also help protect the organs.

I was told something this week about IP6 that was new to me. This patient is having low white blood cell issues. When he uses IP6, he has found they return to normal. I speculate that it is the antioxidant property of IP6 is preventing the white blood cells from being filtered out by the spleen.

Andy,

wanted to know that what are natural chelators and also can you provide some more information about IP6.

Thankx

There are many natural iron chelators, and many herbs like turmeric have iron chelation properties, but two that stand out are IP6 and green tea extract. Both are good supplemental chelators that can remove iron that chelation drugs can't reach. Green tea extract is a concentrated product that does much more than just drinking tea. IP6 is inositol hexaphosphate, a member of the B family of vitamins that is commonly found in the bran of grains like rice. It comes in capsules that can be swallowed or opened and mixed with liquid, but not milk. It should not be taken with milk and is best on an empty stomach with a full glass of water.

Andy,
Thankyou so much for providing the information.