High Alkalyn Phospahte level in lever test

Dear All,

I have 7 year old daughter. In recent lever function test high Alkalyn phosphate level was 300. I am bit worried can any body advise

me on this.

Test Result Normal Range
Liver Function Tests
Units Method
Referred By Triumph Blood Bank
:
Patient's Name Ishanvi Doshi
Referred By
:
Lab No. FCA0965 Reg. Date
:
Sex :Female
Report Date :
Age :
04-Mar-2017 /15:46
08-Mar-2017 /10:56

Test                          Result         Units            Normal Range

Alkaline Phosphatase     300.99         U/L           35.0 - 141.0 PNP DEA Buffer
 Bilirubin (Total)           1.63            mg/dl         0.0 -  1.20 Diazo-Sulphanilic acid
 Bilirubin (Direct)           0.91           mg/dl         0.0  - 0.30 Diazo-Sulphanilic acid
 Bilirubin (Indirect)         0.72           mg/dl         0.0 - 0.90
S.G.O.T./ A.S.T.             27.11          U/L           3.0 - 46.0 IFCC / UV without P5P

S.G.P.T./ A.L.T.              14.02         U/L            3.0 - 42.0 IFCC / UV without PSP
P5PTotal Proteins            6.93           g/dl           6.30 - 8.20 Biuret / End point
Albumin                         3.9             g/dl            3.50 - 5.0 Bromocresol Green
 Globulin                        3.03           g/dl             1.90 - 3.50
A/G ratio                        1.29
GGTP                            16.14          U/L             7.0 - 32.0

Is she using a chelation drug?

Dear Andy Sir,

She is taking Defrijet (750 mg) daily. deferasirox by Sun Pharma.


Regards

Hemendra Doshi

That is the same drug as Exjade, which has a history of raising liver values. Best thing to do is stop chelation for a couple days. Make sure the child is always well hydrated. I cannot stress that enough. When you restart the chelator, try splitting the dose, so part is taken in the morning and the rest later in the day. This makes it easier on the liver. I would also suggest that she take either milk thistle capsules or the supplement, Liv 52. Both are very good for the liver and will help keep these levels down. There may be some mild nausea when first starting milk thistle, but this passes after a couple days.

Thanks Andy Sir