Hello F. It's actually not really important How to split the dose since exjade is supposed to be a once a day medication. The idea to do so is that you can be covered for 24 hours. Best way would be to take 2 tablets every 12 hours if you have to take 4. If your dosage is 3 or 5 tablets you can decide whether it's best to take the most in the morning or in the evening... it's actually up to you.
But the effect is really better by splitting up, I can tell.