My understanding is that one reason deaths in Northern Italy and China are so high is because air pollution is so high in both regions and tobacco smoking is also high in both nations, especially by men, which may account for some of the difference in death by gender. Respiratory ailments do complicate matters for infected people. The thalassemia patients that TIF is aware of, have not had any unusual problems when they ciontract the virus, but these reports are only anecdotal.