Pyruvate Kinase Activation

Would this give credence to the theory of iron, before, the manifestation of Thalassemia?
Since iron inhibits pyruvate kinase?

The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model
https://pubmed.ncbi.nlm.nih.gov/33822774/


Iron-Dependent Oxidative Inactivation with Affinity Cleavage of Pyruvate Kinase.
https://link.springer.com/article/10.1007/s12011-009-8317-x

This looks interesting. Is this treatment in the market now ?

It was just approved in the US in February, 2022.
http://drugapprovalsint.com/mitapivat/

On February 17, 2022, the FDA approved mitapivat as the first disease-modifying treatment for hemolytic anemia in adults with pyruvate kinase (PK) deficiency, a rare, inherited disorder leading to lifelong hemolytic anemia.6 Mitapivat has also been investigated in other hereditary red blood cell disorders associated with hemolytic anemia, such as sickle cell disease and alpha- and beta-thalassemia.1