Still Carry A Thal Major Gene After A Successful BMT?

Hi All

My daughter has undergone a Unrelated Bone Marrow Transplant recently. My doctor told me that even after a successful BMT, my daughter is still carrying the thal major gene and prefebably, she should marry a non thal carrier in order to avoid a thal major baby.

I guess the doctor is right. Any comment?

Thank you.

Dear Omega

I head that a transplant does not change the genotype of the patient, but i also like to know more about this in terms of how transplant switch off these  genes that have the mutation.

Manal

Hi,

Well, we all know that blood is made in the bone marrow (mostly); the transplant is the replacement of the Thal. bone marrow only with the non-Thal. one. The rest of the body still contains the same old-Thal. DNA which is not involved in the manufacture of blood. Therefore, the reproductive system still consists of cells containing the Thal. DNA. which will pass on to the future generation and has nothing to do with bone marrow or it's transplant.

Take care, Peace!