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Thank you Bluebird and Andy,
Great advice.
Already after two to three weeks of taking in the advice in this forum and supplementing good nutritional food with vitamins and wheatgrass, both my daughter and I feel much much better.
I will work with the coaches and make sure that her training regime takes into account recovery times and plan out training and competition sessions.
At this stage we have not told our daughter that she is Thal minor. She is only 8.5 yo and we feel that she is too young to fully understand the significance of it all. Not sure when it would be the right time to bring her into the picture. There is also the thought that if she thinks that she is somewhat disadvantaged compared to other children, it may have a negative psychological effect. I guess this may be a good subject matter to have a separate forum discussion. "At what age do you inform your child in competitive sport that he or she is Thal minor and what it’s all about?"
Cheers and many thanks once again – Sofie
Abstract
Multimodal treatment concepts including liver transplantation for hepatocellular carcinoma (HCC), extended resection methods and neoadjuvant chemotherapy for colorectal liver metastasis significantly improve patients’ outcome. However, surgery-induced hepatic ischemia-reperfusion injury (IRI) and chemotherapy-associated hepatotoxicity result in hepatocellular damage and compromised liver function. Activation of common key pathways in ischemic liver and hepatotoxic injury results in oxidative stress, inflammatory responses and apoptosis causing organ damage. Controlling liver damage before and during surgery is essential for the postoperative outcome. Nigella sativa has a long tradition as a natural remedy. In the essential oil, Thymoquinone (TQ) was identified as the main component and responsible for most of the therapeutic effects. Therefore, this systematic review aimed to summarize the hepatoprotective effects of TQ and its potential suitability to improve surgical outcome by reducing surgical ischemic injury and hepatotoxicity of neoadjuvant chemotherapy. The key findings can be summarized as TQ having strong antioxidant, anti-inflammatory, antifibrotic, anti-/proapoptotic and anticarcinogenic effects. Almost no side effects were reported irrespective of a large dose range, suggesting a wide therapeutic window. These results give rise to the expectation that TQ could evolve to a novel powerful drug to reduce hepatic injury.
Keywords: Nigella sativa, Thymoquinone, natural remedy, liver, ischemia/reperfusion injury, hepatotoxicity, chemotherapy, hepatic injury