If you have not already been tested, you need to be tested to see if you are a thalassemia carrier. This is the most important thing. If you are not a carrier, your children cannot be thal major or intermedia, but would be minors, as they would inherit one thalassemia gene from their father. So, find out what your status is for sure. A hemoglobin electrophoresis test, along with a Complete Blood Count, should be able to determine if you are a thal carrier. If you are, then it does create the possibility of your children being thal major.