As a matter of interest, I'm wondering if anyone/anyone's child carries IVS I nt2 (T-C) mutation? Adel's inherited -28 (A-G) (common mutation from South East Asia) from me and IVS I nt2 (common in the Mediterranean?) from his father. I'm told that doesn't behave like usual Thalassemia. His spleen became large at 6 months old and managing him is more challenging than usual thalassemias here.